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GLYCYRRHIZIC ACID |
| Synonyms. Glycyrrhizic Acid; Glycyrrhizin; Glycyron; Glycyrrizin; Glycyrrhetinic acid glycoside; 18-beta-Glycyrrhizic acid; Liquorice; (3beta,20beta)-20-Carboxy-11-oxo-30-norlean-12-en- 3-yl-2-O-beta-1- 7-glucopyranuronosyl-alpha-D-glucopyranosiduronic acid; 20beta-Carboxy-11- oxo-30-norolean-12-en-3beta-yl-2-O-beta-D-glucopyranuronosyl-alpha-D- glucopyranosiduronic acid; |
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| PRODUCT IDENTIFICATION | |
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CAS RN |
1405-86-3 |
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EINECS RN |
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FORMULA |
C42H62O16 |
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MOLE WEIGHT |
822.93 |
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H.S CODE |
2938.90.0000 |
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SMILES |
C[C@]12CC[C@](C[C@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H] (C([ C@@H]5CC[C@]4([C@ @]3(CC2)C)C)(C)C)O[C@@H]6[C@@H]([C@H] ([C @@H ]([C@H](O6)C(=O)O)O)O)O[C@H]7 [C@@H]([C@H]([C@@H] ([C@ H]( O7 )C(=O)O)O)O)O)C)(C)C(=O)O |
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CLASSIFICATION |
Triterpenoid, Disaccharide |
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EXTRA NOTES |
A widely used anti-inflammatory agent isolated from the licorice root. It is metabolized to glycyrrhetinic acid, which inhibits 11-beta-hydroxysteroid dehydrogenases and other enzymes involved in the metabolism of corticosteroids. Therefore, glycyrrhizic acid, which is the main and sweet component of licorice, has been investigated for its ability to cause hypermineralocorticoidism with sodium retention and potassium loss, edema, increased blood pressure, as well as depression of the renin-angiotensin-aldosterone system. (MeSH) |
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| PHYSICAL AND CHEMICAL PROPERTIES | |
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PHYSICAL STATE. |
yellow to orange powder |
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MELTING POINT |
220 C |
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BOILING POINT |
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DENSITY |
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SOLUBILITY IN WATER |
Freely soluble in hot water |
| SOLVENT SOLUBILITY | Freely soluble in methanol, n-octanol. Practically insoluble in ether, acetone. |
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VAPOR DENSITY |
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log P(octanol-water) |
2.8 |
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VAPOR PRESSURE |
5.22E-34 mm Hg |
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AUTOIGNITION TEMP |
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| pK |
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REFRACTIVE INDEX |
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FLASH POINT |
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| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions. |
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INCOMPATIBLE MATERIALS |
Strong oxidizing agents. |
| POLYMERIZATION |
Has not been reported |
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NFPA RATINGS |
Health: 1, Flammability: 0, Reactivity: 0 |
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| EXTERNAL LINKS & GENERAL DESCRIPTION |
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Wikipedia Linking - Glycyrrhizin Google Scholar Search - Glycyrrhizin Drug Information Portal (U.S. National Library of Medicine) - Glycyrrhizin PubChem Compound Summary - Glycyrrhizin KEGG (Kyoto Encyclopedia of Genes and Genomes) - Glycyrrhizin http://www.ebi.ac.uk/ - Glycyrrhizin http://www.ncbi.nlm.nih.gov/ - Glycyrrhizin http://toxnet.nlm.nih.gov/ |
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| SALES SPECIFICATION | |
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APPEARANCE |
yellow to orange powder |
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ASSAY |
98.0% min |
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LOSS ON DRYING |
5.0% max |
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pH |
2.5 ~ 3.5 |
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HEAVY METALS |
10ppm max |
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| TRANSPORT & REGULATORY INFORMATION | |
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UN NO. |
Not regulated |
| HAZARD CLASS |
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| PACKING GROUP | |
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| SAFETY INFORMATION |
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HAZARD OVERVIEW |
OSHA Hazards;Target Organ Effect. Target Organs:Adrenal cortex. May be harmful if inhaled. May cause respiratory tract irritation. May be harmful if absorbed through skin. May cause skin irritation. May cause eye irritation. May be harmful if swallowed. |
| HAZARD CODES |
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RISK PHRASES |
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SAFETY PHRASES |
24/25 |
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| PACKING |
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Preserve in light-resistant and well-closed containers |